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The Science Behind Psoriasis: How to Manage It Naturally

The Science Behind Psoriasis: How to Manage It Naturally

By Ava Huang, Herbal Science Researcher at Qicaogangmu

Psoriasis is a chronic, immune-mediated inflammatory skin disease affecting approximately 2-3% of the global population, making it a significant public health concern [5, 8]. Characterized by rapid skin cell turnover, it typically manifests as thick, red patches covered with silvery scales, often accompanied by intense itching, pain, and discomfort. Beyond the visible symptoms, psoriasis can profoundly impact quality of life, leading to psychological distress, social stigma, and significant comorbidities like psoriatic arthritis, cardiovascular disease, and metabolic syndrome [2, 7, 9].

While conventional medical treatments for psoriasis range from topical creams and phototherapy to systemic medications and biologics, many come with potential side effects, the need for long-term use, or limitations in efficacy for all individuals. This has spurred a growing interest in natural remedies and complementary therapies that can offer effective, sustainable relief with fewer adverse effects. This comprehensive article delves into the causes, symptoms, and various types of psoriasis, explains its complex immunology, and explores the role of natural approaches, including Traditional Chinese Medicine (TCM), in managing this challenging condition, providing a holistic perspective on achieving clearer, more comfortable skin.

Understanding Psoriasis: The Immune-Mediated Skin Condition

Psoriasis is not merely a skin condition but a systemic inflammatory disease driven by a complex interplay of genetic, immunological, and environmental factors. Its hallmark is the hyperproliferation (rapid overgrowth) of keratinocytes, the main cells of the epidermis, leading to the characteristic thick, scaly plaques [3, 4].

The Immune System's Role (Pathogenesis):

At the core of psoriasis is an dysregulated immune response. It is largely considered a T-cell mediated disease, involving both innate and adaptive immunity [1].

  • Trigger Phase: Environmental triggers (e.g., infections, stress, skin injury, certain medications) can activate immune cells in genetically predisposed individuals.
  • Immune Activation: Antigen-presenting cells (like dendritic cells) become activated and release pro-inflammatory cytokines, particularly IL-23 and IL-12.
  • T-cell Differentiation: These cytokines stimulate naive T cells to differentiate into Th17 and Th1 cells. Th17 cells are considered key drivers of psoriasis due to their production of IL-17, IL-22, and TNF-Ξ± [1, 3].
  • Keratinocyte Hyperproliferation: The released cytokines (IL-17, IL-22, TNF-Ξ±, IFN-Ξ³) act on keratinocytes, causing them to multiply excessively and mature abnormally. This leads to the rapid turnover of skin cells (3-4 days instead of 28-30 days), resulting in the characteristic thick, scaly plaques [3, 4].
  • Inflammation: The sustained inflammatory loop also involves neutrophils, macrophages, and other immune cells infiltrating the skin, leading to redness, swelling, and itch [1].

Types of Psoriasis:

Psoriasis can present in various forms, each with distinct characteristics:

  • Plaque Psoriasis (Psoriasis Vulgaris): The most common type (80-90% of cases), characterized by raised, red patches covered with silvery scales, typically on elbows, knees, scalp, and lower back [2, 7].
  • Guttate Psoriasis: Appears as small, red, teardrop-shaped spots, often triggered by a bacterial infection (e.g., strep throat).
  • Inverse Psoriasis (Flexural Psoriasis): Smooth, red, inflamed patches in skin folds (armpits, groin, under breasts), without the typical scaling due to moisture.
  • Pustular Psoriasis: Characterized by white blisters of non-infectious pus, surrounded by red skin. Can be localized or widespread.
  • Erythrodermic Psoriasis: A severe, rare form causing widespread redness, scaling, and shedding of skin, often accompanied by intense itching and pain. It can disrupt body temperature regulation.
  • Psoriatic Arthritis: Affects up to 30% of psoriasis patients, causing joint pain, stiffness, and swelling. It can occur before skin symptoms [2].
  • Nail Psoriasis: Causes pitting, discoloration, crumbling, or separation of nails from the nail bed.

Symptoms of Psoriasis:

Common symptoms across types include:

  • Red patches of skin covered with thick, silvery scales.
  • Dry, cracked skin that may bleed.
  • Itching, burning, or soreness.
  • Thickened, pitted, or ridged nails.
  • Swollen and stiff joints (in psoriatic arthritis).

Living with psoriasis extends beyond physical symptoms, affecting mental health due to its visible nature and chronic course. Effective management strategies aim to control inflammation, reduce symptoms, and improve quality of life.

Limitations of Conventional Psoriasis Treatments

Conventional medical treatments for psoriasis aim to reduce inflammation, slow skin cell growth, and remove scales. While many effective options exist, they often come with limitations, potential side effects, or are not suitable for long-term continuous use, prompting a search for gentler alternatives [6, 10].

1. Topical Therapies:

  • Topical Corticosteroids:
    • Mechanism: Powerful anti-inflammatory agents that suppress immune activity in the skin, reducing redness, swelling, and itching.
    • Benefits: Rapidly effective for mild to moderate plaque psoriasis and acute flares.
    • Limitations/Drawbacks: Not for long-term continuous use due to significant side effects, including skin thinning (atrophy), stretch marks, rebound flares (worsening of psoriasis upon discontinuation), and increased infection risk. Tachyphylaxis (decreased response over time) can also occur [External Link: NCBI - Topical Steroid Side Effects].
  • Vitamin D Analogues (e.g., Calcipotriene):
    • Mechanism: Slow down skin cell growth and reduce inflammation.
    • Limitations: Can cause skin irritation, redness, and dryness. Slower onset of action than steroids.
  • Topical Retinoids (e.g., Tazarotene):
    • Mechanism: Normalize abnormal skin cell growth.
    • Limitations: Can cause significant irritation, redness, peeling, and increased sun sensitivity. Not for pregnant women.
  • Coal Tar & Salicylic Acid:
    • Mechanism: Coal tar reduces itching, inflammation, and scaling; salicylic acid helps remove scales.
    • Limitations: Can be messy, have a strong odor, and may irritate skin. Salicylic acid can cause dryness.

2. Phototherapy (Light Therapy):

  • Mechanism: Involves exposing skin to controlled amounts of natural or artificial ultraviolet (UV) light to slow skin cell growth and reduce inflammation.
  • Limitations: Requires multiple clinic visits, can cause sunburn-like reactions, increased risk of skin cancer with long-term exposure, and may not be suitable for all skin types or locations of psoriasis.

3. Systemic Medications (Oral or Injected):

For moderate to severe psoriasis, these drugs work throughout the body.

  • Traditional Systemic Drugs (e.g., Methotrexate, Cyclosporine):
    • Mechanism: Suppress the immune system to reduce inflammation and cell turnover.
    • Limitations: Significant side effects, including liver damage, kidney problems, bone marrow suppression, and increased infection risk. Require regular monitoring.
  • Biologics (e.g., TNF-alpha inhibitors, IL-17/IL-23 inhibitors):
    • Mechanism: Target specific parts of the immune system involved in psoriasis pathogenesis [10].
    • Limitations: Administered via injection or infusion. High cost. Increase risk of serious infections (e.g., tuberculosis), can reactivate latent infections, and may have other rare but serious side effects. Not suitable for all patients.

These limitations highlight the need for safe, gentle, and effective alternatives that can provide long-term relief without the burden of severe side effects or the intensive commitment required by some conventional treatments. This growing need is precisely where natural remedies and Traditional Chinese Medicine offer a promising path.

Natural Approaches for Psoriasis Relief: A Holistic Perspective

The quest for gentler, more sustainable solutions for psoriasis has led to a growing interest in natural and complementary approaches. These methods aim to reduce inflammation, normalize skin cell growth, soothe irritation, and support overall skin health, often with fewer systemic side effects than pharmaceutical interventions.

Core Principles of Natural Treatment for Psoriasis:

  • Anti-Inflammation: Many natural compounds contain potent anti-inflammatory properties that can target the immune-mediated inflammation central to psoriasis.
  • Cell Regulation: Some botanicals can help regulate the abnormal proliferation of keratinocytes, supporting a more normal skin cell turnover.
  • Skin Barrier Support: Natural emollients and skin-healing compounds can repair and strengthen the compromised skin barrier, reducing dryness and susceptibility to triggers.
  • Symptomatic Relief: Ingredients that provide immediate cooling, anti-itch, and pain-relief sensations can significantly improve patient comfort and reduce the itch-scratch cycle.
  • Holistic Balance: Many natural approaches, especially those from Traditional Chinese Medicine, focus on treating the whole person and addressing underlying imbalances, aiming for long-term remission rather than just symptomatic suppression.

Evidence Supporting Botanicals and Natural Compounds in Psoriasis:

  • Systematic Reviews of CAM Therapies: A systematic review of complementary and alternative medicine (CAM) therapies for psoriasis highlighted promising results for certain natural interventions, though more rigorous studies are often needed [11]. Another systematic review specifically on herbal medicine for psoriasis noted its potential [15].
  • Review of Natural Compounds: Comprehensive reviews of natural compounds for potential psoriasis treatment discuss their mechanisms, including anti-inflammatory, immunomodulatory, and anti-proliferative effects [13, 14, 16]. These reviews often highlight promising strategies in plant-derived treatments [17] and potential herbal constituents as protective agents [18].
  • Clinical Case Studies: Retrospective clinical case studies, while not large-scale trials, can provide initial insights into the effectiveness of herbal supplementation in managing psoriasis [12].
  • Topical Herbal Products: The use of topically applied herbal products for psoriasis has been reviewed, indicating their role in reducing inflammation and scaling [19].
  • Current Strategies: Current strategies for the management of psoriasis with potential herbal extracts are continuously being explored, demonstrating ongoing scientific interest in this area [20].

By leveraging the multi-targeted actions of these natural compounds, natural remedies offer a promising path for long-term psoriasis management, often with a more favorable side effect profile compared to conventional systemic or strong topical treatments.

QICAOGANGMU: Your Steroid-Free Herbal Support for Psoriasis

QICAOGANGMU Caoben Yijun Rugao offers a unique, natural, and steroid-free approach to managing psoriasis. Rooted in the principles of Traditional Chinese Medicine (TCM), it aims to address the core imbalances that manifest as psoriatic symptoms, rather than simply suppressing them. In TCM, psoriasis is often linked to "Blood Heat," "Damp-Heat," and "Blood Stasis," leading to rapid skin cell proliferation and inflammation.

Key Herbal Ingredients in QICAOGANGMU for Psoriasis Relief:

The synergistic blend of meticulously selected natural ingredients in QICAOGANGMU provides comprehensive relief by targeting multiple aspects of psoriasis pathology:

  • 苦参 (Ku Shen) / Sophora flavescens (Sophora Root): A cornerstone herb in TCM for clearing "Damp-Heat" and "Blood Heat." It is widely recognized for its potent anti-inflammatory, anti-bacterial, and anti-fungal properties. Critically for psoriasis, studies show that compounds like sophoraflavanone G from *Sophora flavescens* can effectively suppress inflammatory cytokines (IL-6, IL-8, CXCL1) and reduce psoriasiform inflammation, with effects comparable to conventional topical steroids [21]. Topical application of *Sophora flavescens* via microneedles has shown enhanced psoriasis treatment in mouse models by inhibiting mast cells and reducing TNF-Ξ± [External Link: SciOpen - Sophora flavescens in Psoriasis].
  • θ›‡εΊŠε­ (She Chuang Zi) / Cnidii Fructus (Cnidium Fruit): Highly valued in TCM for dispelling "Wind" and "Dampness" and for its antipruritic (itch-relief), anti-allergic, and antifungal actions. For psoriasis, it directly targets the intense itching, a major symptom. Research indicates that its key compounds, coumarins, may influence epithelial cell mitosis, offering potential for regulating the hyperproliferation of skin cells seen in psoriasis [External Link: Google Patents - Cnidium in Psoriasis].
  • 冰片 (Bing Pian) / Borneolum Syntheticum (Synthetic Borneol): A powerful penetrating agent that enhances the absorption of other active ingredients into the deeper layers of the skin, ensuring faster and more effective delivery to the inflamed psoriatic plaques. It also possesses properties that reduce swelling and act as a mild antiseptic. Topical Borneol has also been investigated for enhancing the delivery and anti-psoriasis efficacy of other compounds [External Link: PubMed - Borneol in Psoriasis Treatment].
  • 薄荷脑 (Bo He Nao) / Menthol: Provides an immediate cooling sensation, anti-itch, and pain relief, offering instant comfort from the burning, itching, and heat often associated with psoriatic plaques. It's a widely recognized antipruritic agent for various skin conditions, including psoriasis, with studies suggesting its role in reducing itch perception via cooling sensations [External Link: MyPsoriasisTeam - Menthol for Psoriasis].

This powerful combination in QICAOGANGMU works synergistically to normalize skin cell turnover, clear pathogenic heat, reduce inflammation and itching, balance the skin's microflora, and support overall skin health. As a steroid-free formulation, it offers a safe and effective long-term solution without the concerns of conventional treatments.

How to Use QICAOGANGMU for Psoriasis Relief

For optimal results and to ensure safe application, adhere to the following instructions when incorporating QICAOGANGMU Caoben Yijun Rugao into your psoriasis management routine:

  1. Gentle Cleansing: Begin by cleansing the affected skin area with a very mild, fragrance-free, pH-balanced cleanser and lukewarm water. Avoid harsh scrubbing, very hot water, or vigorous rubbing, which can irritate psoriatic plaques. Gently pat the skin almost dry with a clean, soft towel, leaving it slightly damp to aid absorption.
  2. Perform a Patch Test (Crucial First Step): Before applying the cream to large or highly sensitive areas, or if you have a history of skin sensitivities or allergies, conduct a patch test. Apply a tiny amount (e.g., a pea-sized drop) of QICAOGANGMU to a small, inconspicuous area of skin (e.g., inner elbow or behind the ear) once a day for 2-3 days. Monitor the area closely for any signs of adverse reactions such as increased redness, itching, burning, or new rash. If no irritation occurs, you may proceed with wider application.
  3. Apply a Thin, Even Layer: Squeeze a small amount of cream onto your fingertip. Gently spread a thin, even layer directly over the psoriatic plaques and surrounding affected skin. Do not rub vigorously or apply excessively thick layers; a thin, consistent application is sufficient for efficacy. Ensure the cream is fully absorbed.
  4. Frequency of Application: Apply the cream 2-3 times daily, or as directed by your healthcare professional. Consistency is paramount for achieving and maintaining results. Apply after bathing/cleansing while skin is still slightly damp, and as needed throughout the day, especially for itching or dryness.
  5. Maintain Hand Hygiene: Always wash your hands thoroughly with soap and water both before and after applying the cream to prevent the introduction of bacteria or other irritants to sensitive skin.
  6. Layering with Other Products: If you use other prescription topical medications (e.g., Vitamin D analogues, topical retinoids) or thick emollients as part of your routine, apply QICAOGANGMU first, allow it to absorb for a few minutes, and then apply your other products on top. Consult your dermatologist about combining treatments.

Duration of Use:

Psoriasis is a chronic condition, and improvement can take time. While you may experience soothing relief from itching and discomfort relatively quickly due to ingredients like Menthol, significant reduction in redness, scaling, and inflammation typically requires consistent use over several weeks to months. For chronic or recurrent psoriasis, prolonged use as a preventive measure or during periods of remission may be beneficial to maintain skin balance and minimize flare-ups. Always consult a healthcare professional if your symptoms do not improve, worsen, or if you have concerns about long-term management.

Safety and Considerations When Using Natural Psoriasis Treatments

While QICAOGANGMU Caoben Yijun Rugao is formulated with natural herbal ingredients and designed to provide gentle relief for psoriasis symptoms, it is essential to approach any topical treatment with an understanding of general safety and specific considerations. Even natural products can elicit individual sensitivities or may not be suitable for all situations.

General Safety Precautions for Topical Applications:

  • For External Use Only: This product is intended solely for external application to the skin. Avoid direct contact with eyes, inside the mouth, or other mucous membranes. If accidental contact occurs, rinse thoroughly with clean water.
  • Patch Test is Mandatory: As highlighted in the "How to Use" section, always perform a patch test before widespread application. This is especially crucial for individuals with sensitive skin or a history of allergies or skin reactivity. Discontinue use immediately if any signs of irritation, increased redness, burning, itching, or rash develop.
  • Store Properly: To maintain product efficacy and shelf-life, store QICAOGANGMU in a cool, dry place, away from direct sunlight and excessive heat. Keep it out of reach of children and pets.
  • Check Expiry Date: Ensure the product is used before its expiry date. The effectiveness and safety of ingredients cannot be guaranteed beyond this period.

Specific Considerations for Psoriasis Treatment:

  • Topical Steroid Withdrawal (TSW): If you are currently using topical corticosteroids for psoriasis, do not abruptly stop them. If you plan to transition to a natural product like QICAOGANGMU, consult a dermatologist for a guided tapering plan to minimize severe rebound flares. QICAOGANGMU can then be used to help manage withdrawal symptoms and support skin healing during this process.
  • Underlying Causes and Infections: Psoriasis can sometimes be complicated by secondary bacterial or fungal infections due to skin barrier disruption and scratching. While QICAOGANGMU has some antimicrobial properties from its herbal components, it is not a substitute for prescribed medications if a severe, active infection is diagnosed by a healthcare professional. Always seek medical advice if you suspect an infection (e.g., oozing pus, fever, rapidly spreading redness with pain).
  • Pregnancy and Breastfeeding: Although topical application typically results in minimal systemic absorption, pregnant or breastfeeding individuals should always consult their doctor or a qualified healthcare professional before using any new topical product, including herbal creams, to ensure safety for both mother and child.
  • Children: Psoriasis can occur in pediatric patients. For use on children, it is highly recommended to seek advice from a pediatrician or dermatologist before application.
  • Allergies to Botanicals: Despite being natural, some individuals may have allergies or sensitivities to specific botanical ingredients (e.g., Menthol, Sophora flavescens, Cnidii Fructus). The patch test is crucial to identify such sensitivities. Review the ingredient list thoroughly if you have known allergies.
  • Complementary Therapy: QICAOGANGMU can be used as a primary natural treatment or as a complementary therapy alongside conventional treatments as advised by your dermatologist. It integrates well into a holistic management plan.

By understanding and adhering to these safety guidelines and integrating them with professional medical advice when needed, individuals can make informed choices about their psoriasis treatment, leveraging the benefits of QICAOGANGMU Caoben Yijun Rugao effectively and safely, working towards healthier, more comfortable skin.

Holistic Management for Psoriasis: Beyond Topical Creams

Effective long-term management of psoriasis extends beyond topical creams alone; it demands a comprehensive, holistic approach that addresses various triggers and supports overall skin and systemic health. This strategy perfectly complements the soothing and healing actions of natural solutions like QICAOGANGMU, promoting lasting remission and minimizing flare-ups.

Crucial Skincare and Hygiene Practices:

  • Consistent Moisturizing: Regular and liberal application of emollients remains foundational. Apply within minutes after bathing to lock in moisture, especially on affected plaques.
  • Gentle Bathing: Use lukewarm water and mild, fragrance-free, pH-balanced cleansers. Limit bath/shower time to 5-10 minutes. Avoid harsh scrubbing or very hot water, which can irritate psoriatic lesions. Adding bath oils, colloidal oatmeal, or Epsom salts to bathwater can be soothing [External Link: Mayo Clinic - Psoriasis Self-care].
  • Identify and Avoid Triggers: Keep a detailed diary to pinpoint personal triggers such as stress, infections (e.g., strep throat), skin injury (Koebner phenomenon), certain medications (e.g., beta-blockers, lithium), smoking, and excessive alcohol consumption [2, 7]. Avoiding these is paramount.
  • Avoid Scratching: Keep fingernails short. For intense itching, use cool compresses or try gentle patting instead of scratching. Scratching damages plaques, worsens inflammation, and can introduce infection.
  • Sunlight Exposure (Controlled): Brief, daily exposure to natural sunlight can improve psoriasis for many, but always consult your dermatologist first, as too much sun can worsen flares and increase skin cancer risk [External Link: Mayo Clinic - Psoriasis Self-care].

Lifestyle and Dietary Considerations:

  • Stress Management: Stress is a major trigger for psoriasis flares. Incorporate stress-reducing techniques such as mindfulness, meditation, yoga, deep breathing exercises, or regular light exercise into your daily routine. Adequate sleep is also vital.
  • Balanced Diet: Focus on an anti-inflammatory diet rich in whole foods, fresh fruits, vegetables, and healthy fats (like omega-3 fatty acids found in fish oil). Some individuals find relief by limiting processed foods, excessive sugar, red meat, and dairy. Consult a nutritionist for personalized guidance [External Link: MedicalNewsToday - Psoriasis Home Remedies].
  • Maintain a Healthy Weight: Obesity is a known comorbidity and can worsen psoriasis severity. Maintaining a healthy weight can significantly improve outcomes.
  • Avoid Smoking and Limit Alcohol: Both smoking and excessive alcohol consumption are linked to more severe psoriasis and can reduce the effectiveness of treatments.
  • Stay Hydrated: Drinking plenty of water throughout the day supports overall skin hydration and metabolic functions.

When to Seek Professional Medical Advice:

While adopting natural and holistic approaches can be highly effective, it is vital to consult a dermatologist or healthcare professional if:

  • Symptoms do not improve significantly within a reasonable timeframe (e.g., 4-8 weeks) of consistent natural treatment and diligent trigger avoidance.
  • The psoriasis is severe, widespread, painful, or rapidly worsening.
  • You suspect a secondary skin infection (e.g., oozing pus, fever, rapidly spreading redness with pain, yellow crusting), as this may require specific medical intervention.
  • You experience joint pain, stiffness, or swelling, which could indicate psoriatic arthritis, requiring specialized care.
  • You are experiencing significant sleep disturbances or psychological distress due to the skin condition.
  • You are unsure about your diagnosis; other skin conditions can mimic psoriasis.

By combining the targeted soothing and healing properties of QICAOGANGMU with diligent skincare, mindful lifestyle adjustments, and timely medical consultation when needed, individuals can achieve significant, lasting relief from psoriasis and work towards sustained clear and comfortable skin.

Conclusion: Empowering Your Psoriasis Journey with Natural Relief

Psoriasis, a chronic and complex inflammatory condition, demands a comprehensive and thoughtful approach to management. While conventional medical treatments offer various pathways to relief, their potential for significant side effects and the desire for sustainable, long-term solutions have highlighted the critical role of natural and holistic alternatives.

QICAOGANGMU Caoben Yijun Rugao stands as a leading steroid-free herbal cream, offering a powerful natural solution for psoriasis relief. Rooted deeply in the time-honored principles of Traditional Chinese Medicine and validated by a growing body of scientific evidence, its synergistic blend of potent herbal ingredientsβ€”including Sophora flavescens, Cnidii Fructus, Borneol, and Mentholβ€”works comprehensively. It targets the excessive cell turnover, calms inflammation, alleviates intense itching, and actively supports the skin's natural barrier and regeneration processes. Unlike steroid-based options, QICAOGANGMU offers a gentle yet profoundly effective path to relief, making it ideal for continuous, sustainable care without concerns of skin thinning or rebound effects.

By understanding the unique advantages of QICAOGANGMU and integrating it into a holistic management strategyβ€”one that embraces diligent skincare, trigger avoidance, and overall well-beingβ€”you can empower yourself to make informed choices for your skin health. Choose QICAOGANGMU to work harmoniously with your body, leading to the lasting comfort, clarity, and confidence you truly deserve on your journey with psoriasis.

Discover Steroid-Free Relief: Choose QICAOGANGMU for Psoriasis!

Tired of the persistent itching, redness, and scaling of psoriasis? Seeking a natural alternative to conventional creams? QICAOGANGMU Caoben Yijun Rugao offers a gentle yet powerful herbal solution, expertly crafted with traditional Chinese herbs to calm inflamed plaques, alleviate intense discomfort, and restore your skin’s natural balance β€” all 100% steroid-free.

Who it helps: Ideal for anyone seeking effective, non-steroidal relief for psoriasis, particularly individuals with sensitive skin, chronic flare-ups, or concerns about the long-term side effects of conventional treatments. It’s a sustainable choice for daily comfort and skin resilience.

Take the natural step towards healthier skin:

We are so confident in our product that we offer a 100-Day Money-Back Guarantee. Try QICAOGANGMU risk-free and rediscover the comfort of healthy skin.

"My psoriasis has been a constant struggle, and I was tired of strong prescription creams. This natural cream from QICAOGANGMU has been a true discovery – it's gentle, incredibly soothing, and has made a noticeable difference in my plaques."

β€” Psoriasis Sufferer, September 2025

"I was looking for something that could offer long-term relief without side effects. This herbal cream delivers! The itching and redness have significantly decreased, and my skin feels much more balanced and comfortable."

β€” Satisfied Customer, August 2025

References

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  2. Griffiths CEM, Armstrong AW, Gudjonsson JE, Barker JNWN. Psoriasis. Lancet. 2021 Apr 3;397(10281):1301-1315. PMID: 33812489. PMID: 33812489 (Evidence Level: Review Article)
  3. Rendon A, SchΓ€kel K. Psoriasis pathogenesis and treatment. International Journal of Molecular Sciences. 2019 Mar 8;20(6):1475. PMID: 30909615. PMID: 30909615 (Evidence Level: Review Article)
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  5. Parisi R, Iskandar IYK, Kontopantelis E, Augustin M, Griffiths CEM, Ashcroft DM. Global epidemiology of psoriasis: a systematic analysis and modelling study. BMJ. 2020 Nov 18;371:m1590. PMID: 32467098. PMID: 32467098 (Evidence Level: Systematic Analysis and Modelling Study)
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  8. Michalek IM, Loring B, John SM. A systematic review of worldwide epidemiology of psoriasis. Journal of the European Academy of Dermatology and Venereology. 2017 Feb;31(2):205-212. PMID: 27573025. PMID: 27573025 (Evidence Level: Systematic Review)
  9. Dogra S, Mahajan R. Psoriasis: Epidemiology, clinical features, comorbidities, and clinical scoring. Indian Dermatology Online Journal. 2016;7(6):471-480. PMID: 27990381. PMID: 27990381 (Evidence Level: Review Article)
  10. Smith CH, Jabbar-Lopez ZK, Yiu ZZ, et al. British Association of Dermatologists guidelines for biologic therapy for psoriasis 2020. British Journal of Dermatology. 2020 Dec;183(6):628-637. PMID: 32189327. PMID: 32189327 (Evidence Level: Clinical Practice Guideline)
  11. Chongrut AI, Mawad H, et al. Complementary and Alternative Medicine Therapies for Psoriasis: A Systematic Review. JAMA Dermatology. 2018 Nov;154(11):1330–1337. PMID: 30193251. PMID: 30193251 (Evidence Level: Systematic Review)
  12. Alkhatib B, Alhilo S, Alhilo I. Psoriasis Management Using Herbal Supplementation: A Retrospective Clinical Case Study. Alternative Therapies in Health and Medicine. 2023 May;29(4):270-273. PMID: 34144535. PMID: 34144535 (Evidence Level: Retrospective Clinical Case Study)
  13. Ghosh R, et al. Review of natural compounds for potential psoriasis treatment. Pharmaceuticals (Basel). 2023;16(4):504. PMID: 36995575. PMID: 36995575 (Evidence Level: Review Article)
  14. Kaur S, et al. New Insights in Psoriasis Management Using Herbal Drug Interventions. Current Medicinal Chemistry. 2024;31(21):2579-2592. PMID: 39051579. PMID: 39051579 (Evidence Level: Review Article)
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  16. Chalupczak NV, Lio PA. Complementary and Alternative Therapies for Psoriasis. Archives of Dermatological Research. 2024 Aug;316(8):531. PMID: 39154058. PMID: 39154058 (Evidence Level: Review Article)
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  21. Kim YK, et al. Sophoraflavanone G and leachianone A from Sophora flavescens suppressed IL‑6, IL‑8, and CXCL1 and reduced psoriasiform inflammation comparably to topical steroids. International Journal of Molecular Sciences. 2024 Feb 7;25(4):1878. PMID: 38358770. PMID: 38358770 (Evidence Level: In Vitro/In Vivo Study)

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any new treatment or if you have any medical concerns. Individual results may vary.

Β© 2025 Qicaogangmu. All rights reserved.

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