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Understanding Herbal Compounds in Chinese Medicine for Eczema Relief

Understanding Herbal Compounds in Chinese Medicine for Eczema Relief

By Ava Huang, Herbal Science Researcher at Qicaogangmu

Eczema, medically known as atopic dermatitis (AD), is a chronic inflammatory skin condition characterized by dry, itchy, red patches, often with oozing or crusting. In Western medicine, it's understood as a complex interplay of genetic predisposition, immune system dysfunction, and environmental triggers. While conventional treatments often focus on managing symptoms with topical steroids and immunomodulators, Traditional Chinese Medicine (TCM) offers a unique and holistic perspective, viewing eczema as an external manifestation of internal imbalances.

Chinese Herbal Medicine (CHM) has a long history of use in treating eczema, with a rich tradition of complex formulas designed to restore the body's internal harmony. This comprehensive article will delve into the scientific understanding of key herbal compounds commonly used in CHM for eczema relief. We will explore how these natural ingredients, often found in synergistic formulas, work to alleviate symptoms like inflammation and itching, support skin barrier function, and address the underlying pathogenic factors identified in TCM, providing a deeper understanding of how products like QICAOGANGMU Caoben Yijun Rugao offer effective, steroid-free relief for eczema.

The Foundation: Eczema Through a TCM Lens

In Traditional Chinese Medicine, the skin is seen as a reflection of the body's internal state. Eczema is not merely a localized skin problem but a symptom of disharmony within the body's organ systems and the imbalance of vital substances like Qi (vital energy), Blood, Yin (cooling, nourishing aspects), and Yang (warming, active aspects), and the harmonious flow of these elements through meridians (energy pathways). The primary pathogenic factors that manifest as eczema are often categorized as 'Wind,' 'Dampness,' and 'Heat,' which can combine in various ways to produce different clinical presentations [1, 3].

Key TCM Concepts Applied to Skin Health:

  • Damp-Heat: A common pathogenic factor in TCM, often associated with skin conditions characterized by redness, swelling, oozing, itching, and a feeling of heat. This imbalance can arise from dietary factors (e.g., excessive greasy, spicy, or sweet foods), environmental humidity, or internal metabolic dysfunction. Many inflammatory rashes, including eczema, allergic reactions, and fungal infections, align with Damp-Heat patterns.
  • Wind: In TCM, "Wind" is a pathogenic factor known for its rapid movement, sudden onset, and migratory nature. It is often described as "the chief of the hundred diseases" because it can carry other pathogenic factors. When Wind affects the skin, it typically causes intense, migratory itching that can appear suddenly and change locations.
  • Heat: Characterized by its inflammatory, burning, and red qualities. It consumes Yin (cooling fluids) and can cause rapid changes. When Heat is prominent, the skin will be intensely red, inflamed, hot to the touch, and may have a burning sensation. Acute flares with bright red lesions and severe inflammation are typical of Heat patterns.
  • Blood Heat / Toxic Heat: Refers to excessive internal heat that can manifest as chronic redness, severe inflammation, and rapid skin cell turnover, as seen in conditions like psoriasis. "Toxic Heat" implies a more intense, potentially infectious, or severe inflammatory process.
  • Qi & Blood Stagnation: When the flow of Qi and Blood is impeded, it can lead to chronic, persistent lesions, pain, and poor healing. This is often seen in long-standing skin conditions.
  • Skin Barrier Function: While not a direct TCM term, the concept of maintaining the skin's integrity and resistance to external pathogens aligns with TCM's emphasis on strengthening the body's defensive Qi.

QICAOGANGMU's herbal formula is meticulously designed to address these TCM patterns. It aims to "clear Heat," "resolve Dampness," "dispel Wind," "detoxify," and "invigorate Blood" at the affected skin site, thereby restoring balance and promoting natural healing.

Scientific Insights into Chinese Herbal Medicine for Eczema

Modern scientific research is increasingly validating the efficacy and mechanisms of action of Chinese herbal medicine for eczema. Systematic reviews and randomized controlled trials (RCTs) provide a growing body of evidence supporting the use of CHM as a complementary or alternative therapy.

  • Overall Efficacy and Safety: Systematic reviews and meta-analyses of RCTs have indicated that traditional Chinese medicine can be effective and safe for atopic dermatitis, showing improvements in symptoms and quality of life [5, 6].
  • Targeting TCM Patterns: Research has identified specific CHM formulas that target the "wind-dampness-heat pattern" in eczema, such as Xiao-Feng-San [1].
  • Clinical Trial Support: Randomized, double-blind, placebo-controlled trials have demonstrated the efficacy and safety of Chinese herbal products like Xiao-Feng-San for refractory atopic dermatitis, showing significant improvements in disease severity scores [2]. Other studies on Chinese herbal medicine concoctions have also shown positive results for atopic dermatitis treatment [4].
  • Immunomodulatory Effects: Studies on herbal extracts, such as Gardenia jasminoides, show they can improve atopic dermatitis-like skin lesions in mice by suppressing Th2-related cytokines and restoring barrier function [7, 8]. This aligns with Western understanding of eczema's immune basis.

This growing body of evidence underscores the potential of Chinese herbal medicine as a valuable approach in eczema management.

QICAOGANGMU: A Targeted Herbal Formula for Eczema Relief

QICAOGANGMU Caoben Yijun Rugao is a steroid-free topical cream formulated with key herbal ingredients that align with the TCM principles of clearing Wind, Dampness, and Heat, while also providing scientifically validated anti-inflammatory, antipruritic, and skin-healing effects specific to eczema.

Key Herbal Compounds and Their Actions in QICAOGANGMU:

The synergistic blend of meticulously selected natural ingredients in QICAOGANGMU provides comprehensive relief by targeting multiple aspects of eczema pathology:

  • ่‹ฆๅ‚ (Ku Shen) / Sophora flavescens (Sophora Root):
    • TCM Actions: Clears Damp-Heat, expels Wind, kills parasites, stops itching.
    • Scientific Actions: Recognized for its potent anti-inflammatory, anti-bacterial, and anti-fungal properties. Its flavonoids (e.g., sophoraflavanone G) and alkaloids (e.g., oxymatrine) suppress inflammatory cytokines (IL-6, IL-8, CXCL1, TNF-ฮฑ, IL-1ฮฒ) and inhibit inflammatory pathways, reducing psoriasiform and general skin inflammation [9]. It has strong antipruritic effects on acute and chronic itch in dermatitis models [10]. Oxymatrine targets proteins involved in chronic, histamine-independent itching [11]. Topical herbal formulae with *Sophora flavescens* root improve psoriasis outcomes via anti-inflammatory and antiproliferative actions [12]. Its immunomodulatory effects include affecting mast cell degranulation, relevant in allergic reactions [19].
  • ่›‡ๅบŠๅญ (She Chuang Zi) / Cnidii Fructus (Cnidium Fruit):
    • TCM Actions: Dries Dampness, expels Wind, kills parasites, stops itching.
    • Scientific Actions: Highly valued for its strong antipruritic (itch-relief), anti-allergic, and antifungal actions. Its coumarins (e.g., osthole) are known for anti-allergic effects in dermatitis and anaphylaxis models [13] and broad antimicrobial properties relevant to skin conditions [14]. It helps balance skin microflora and supports skin barrier function.
  • ๅ†ฐ็‰‡ (Bing Pian) / Borneolum Syntheticum (Synthetic Borneol):
    • TCM Actions: Clears Heat, reduces swelling, alleviates pain, enhances penetration.
    • Scientific Actions: A powerful penetrating agent that enhances the absorption of other active ingredients into the deeper layers of the skin, ensuring faster and more effective delivery. It possesses properties that reduce swelling and acts as a mild antiseptic. Borneol significantly reduces acute and chronic itch by modulating TRPA1 and TRPM8 ion channels [15] and alleviates inflammation and pain by inhibiting immune cell infiltration and downregulating inflammatory cytokines (ILโ€‘6, TNFโ€‘ฮฑ, ILโ€‘8) [16].
  • ่–„่ท่„‘ (Bo He Nao) / Menthol:
    • TCM Actions: Dispels Wind-Heat, clears head and eyes, soothes skin.
    • Scientific Actions: Provides an immediate cooling sensation, anti-itch, and pain relief by activating TRPM8 receptors. Its benefits extend to supporting wound healing by reducing inflammatory cytokines (TNFโ€‘ฮฑ & ILโ€‘6) and boosting antioxidant enzymes [17], aiding in the repair of skin damaged by scratching. It's a widely recognized antipruritic agent [18].

This powerful combination in QICAOGANGMU works synergistically to clear pathogenic factors, reduce inflammation, alleviate itching, balance the skin's microflora, and support overall skin health. As a steroid-free formulation, it offers a safe and effective long-term solution without the concerns of conventional treatments.

How to Use QICAOGANGMU for Eczema Relief

For optimal results and to ensure safe application, adhere to the following instructions when incorporating QICAOGANGMU Caoben Yijun Rugao into your eczema management routine:

  1. Gentle Cleansing: Begin by cleansing the affected skin area with a very mild, fragrance-free, pH-balanced cleanser and lukewarm water. Avoid harsh scrubbing, very hot water, or vigorous rubbing, which can further irritate sensitive and inflamed skin. Gently pat the skin almost dry with a clean, soft towel, leaving it slightly damp to aid absorption.
  2. Perform a Patch Test (Crucial First Step): Before applying the cream to large or highly sensitive areas, or if you have a history of skin sensitivities or allergies, conduct a patch test. Apply a tiny amount (e.g., a pea-sized drop) of QICAOGANGMU to a small, inconspicuous area of skin (e.g., inner elbow or behind the ear) once a day for 2-3 days. Monitor the area closely for any signs of adverse reactions such as increased redness, itching, burning, or new rash. If no irritation occurs, you may proceed with wider application.
  3. Apply a Thin, Even Layer: Squeeze a small amount of cream onto your fingertip. Gently spread a thin, even layer directly over the eczema patches and surrounding inflamed skin. Do not rub vigorously or apply excessively thick layers; a thin, consistent application is sufficient for efficacy. Ensure the cream is fully absorbed.
  4. Frequency of Application: Apply the cream 2-3 times daily, or as directed by your healthcare professional. Consistency is paramount for achieving and maintaining results. Apply after bathing/cleansing while skin is still slightly damp, and as needed throughout the day, especially when itch or irritation intensifies.
  5. Maintain Hand Hygiene: Always wash your hands thoroughly with soap and water both before and after applying the cream to prevent the introduction of bacteria or other irritants to sensitive skin.
  6. Layering with Other Products: If you use other emollients or prescription topical medications as part of your routine, apply QICAOGANGMU first, allow it to absorb for a few minutes, and then apply your other products on top. Consult your dermatologist about combining treatments.

Duration of Use:

Eczema is a chronic condition, and improvement can take time. While you may experience soothing relief from itching and discomfort relatively quickly, significant reduction in redness, scaling, and inflammation typically requires consistent use over several weeks to months. For chronic or recurrent eczema, prolonged use as a preventive measure or during periods of remission may be beneficial to maintain skin balance and minimize flares. Always consult a healthcare professional if your symptoms do not improve, worsen, or if you have concerns about long-term management.

Safety and Considerations When Using Herbal Eczema Treatments

While QICAOGANGMU Caoben Yijun Rugao is formulated with natural herbal ingredients and designed to provide gentle relief for eczema symptoms, it is essential to approach any topical treatment with an understanding of general safety and specific considerations. Even natural products can elicit individual sensitivities or may not be suitable for all situations.

General Safety Precautions for Topical Applications:

  • For External Use Only: This product is intended solely for external application to the skin. Avoid direct contact with eyes, inside the mouth, or other mucous membranes. If accidental contact occurs, rinse thoroughly with clean water.
  • Patch Test is Mandatory: As highlighted in the "How to Use" section, always perform a patch test before widespread application. This is especially crucial for individuals with sensitive skin or a history of allergies or skin reactivity. Discontinue use immediately if any signs of irritation, increased redness, burning, itching, or rash develop.
  • Store Properly: To maintain product efficacy and shelf-life, store QICAOGANGMU in a cool, dry place, away from direct sunlight and excessive heat. Keep it out of reach of children and pets.
  • Check Expiry Date: Ensure the product is used before its expiry date. The effectiveness and safety of ingredients cannot be guaranteed beyond this period.

Specific Considerations for Eczema Treatment:

  • Topical Steroid Withdrawal (TSW): If you are currently using topical corticosteroids for eczema, do not abruptly stop them. If you plan to transition to a natural product like QICAOGANGMU, consult a dermatologist for a guided tapering plan to minimize severe rebound flares. QICAOGANGMU can then be used to help manage withdrawal symptoms and support skin healing during this process.
  • Underlying Causes and Infections: Eczema can sometimes be complicated by secondary bacterial, fungal, or viral infections due to skin barrier disruption and scratching. While QICAOGANGMU has some antimicrobial properties from its herbal components, it is not a substitute for prescribed medications if a severe, active infection is diagnosed by a healthcare professional. Always seek medical advice if you suspect an infection (e.g., oozing pus, fever, rapidly spreading redness with pain).
  • Pregnancy and Breastfeeding: Although topical application typically results in minimal systemic absorption, pregnant or breastfeeding individuals should always consult their doctor or a qualified healthcare professional before using any new topical product, including herbal creams, to ensure safety for both mother and child.
  • Children: Eczema is common in children. For use on pediatric patients, it is highly recommended to seek advice from a pediatrician or dermatologist before application.
  • Allergies to Botanicals: Despite being natural, some individuals may have allergies or sensitivities to specific botanical ingredients (e.g., Menthol, Sophora flavescens, Cnidii Fructus). The patch test is crucial to identify such sensitivities. Review the ingredient list thoroughly if you have known allergies.
  • Complementary Therapy: QICAOGANGMU can be used as a primary natural treatment or as a complementary therapy alongside conventional treatments as advised by your dermatologist. It integrates well into a holistic management plan.

By understanding and adhering to these safety guidelines and integrating them with professional medical advice when needed, individuals can make informed choices about their eczema treatment, leveraging the benefits of QICAOGANGMU Caoben Yijun Rugao effectively and safely, working towards healthier, more comfortable skin.

Holistic Management for Eczema: Beyond Topical Creams

Effective long-term management of eczema extends beyond topical creams alone. It demands a comprehensive, holistic approach that addresses various triggers, supports overall skin and systemic health, and manages the psychological impact of persistent itch. This strategy perfectly complements the soothing and healing actions of natural solutions like QICAOGANGMU, promoting lasting relief and minimizing flares.

Crucial Skincare and Hygiene Practices:

  • Consistent Moisturizing: Regular and liberal application of emollients remains foundational, even when using QICAOGANGMU. Apply within minutes after bathing to lock in moisture, especially on affected areas. Choose fragrance-free, hypoallergenic moisturizers.
  • Gentle Bathing: Use lukewarm water (not hot) and mild, fragrance-free, pH-balanced cleansers. Limit bath/shower time to 5-10 minutes. Avoid harsh scrubbing or very hot water, which can strip natural oils and exacerbate eczema. Adding colloidal oatmeal or baking soda to bathwater can be soothing.
  • Identify and Avoid Triggers: Keep a detailed diary to pinpoint personal triggers such as certain fabrics (wool, synthetics), harsh soaps, detergents, perfumes, dust mites, pet dander, excessive sweating, or specific foods. Avoiding these is paramount.
  • Avoid Scratching: This is critical for breaking the itch-scratch cycle. Keep fingernails short. For intense itching, use cool compresses, gentle patting, or apply pressure instead of scratching. Consider wearing cotton gloves at night.
  • Maintain a Cool Environment: Heat and sweating can worsen eczema. Keep your living and sleeping environment cool and humidified if the air is dry.

Lifestyle and Dietary Considerations:

  • Stress Management: Stress is a major exacerbating factor for eczema flares. Incorporate stress-reducing techniques such as mindfulness, meditation, yoga, deep breathing exercises, or regular light exercise into your daily routine. Adequate, uninterrupted sleep is also vital for skin healing and itch management.
  • Balanced Diet: Focus on an anti-inflammatory diet rich in whole foods, fresh fruits, vegetables, and healthy fats (like omega-3 fatty acids). Some individuals find relief by identifying and avoiding common food allergens or inflammatory foods (e.g., highly processed foods, excessive sugar, alcohol). Consult a nutritionist for personalized guidance.
  • Wear Breathable Clothing: Opt for loose-fitting clothing made from soft, natural fibers like cotton. Avoid synthetic fabrics and wool, which can trap heat and moisture or cause irritation.
  • Stay Hydrated: Drinking plenty of water throughout the day supports overall skin hydration and metabolic functions.

When to Seek Professional Medical Advice:

While adopting natural and holistic approaches can be highly effective, it is vital to consult a dermatologist or healthcare professional if:

  • Your eczema is new, severe, widespread, or rapidly worsening.
  • Symptoms do not improve significantly within a reasonable timeframe (e.g., 2-4 weeks) of consistent natural treatment and diligent trigger avoidance.
  • You suspect a secondary skin infection (e.g., oozing pus, fever, rapidly spreading redness with pain, yellow crusting), as this may require specific medical intervention.
  • You are experiencing significant sleep disturbances or psychological distress (anxiety, depression) due to the eczema.
  • You have other unexplained symptoms such as fatigue, weight loss, fever, or changes in bowel habits, which could indicate a systemic underlying cause.
  • You are unsure about your diagnosis; many conditions can mimic eczema.

By combining the targeted soothing and healing properties of QICAOGANGMU with diligent skincare, mindful lifestyle adjustments, and timely medical consultation when needed, individuals can achieve significant, lasting relief from eczema and work towards sustained comfort and well-being.

Conclusion: Embracing the Science of Herbal Compounds for Eczema Relief

Understanding the intricate world of herbal compounds in Chinese Medicine for eczema relief reveals a powerful synergy between ancient wisdom and modern science. Far beyond mere symptom suppression, these natural ingredients work holistically to address the root imbalances of 'Wind,' 'Dampness,' and 'Heat,' which are central to the TCM understanding of eczema.

QICAOGANGMU Caoben Yijun Rugao embodies this scientific and traditional harmony. Its meticulously crafted, steroid-free formula leverages the synergistic actions of key ingredients like Sophora flavescens, Cnidii Fructus, Borneol, and Menthol. These compounds work synergistically to powerfully reduce inflammation, alleviate intense and persistent itching, combat microbial overgrowth, enhance absorption for deeper action, and actively support the skin's natural barrier and regeneration processes. This comprehensive approach offers a gentle yet profoundly effective path to relief, making QICAOGANGMU an ideal solution for continuous, sustainable eczema care without concerns of harshness or rebound effects.

By choosing QICAOGANGMU, you are opting for a natural solution that is both deeply rooted in centuries of herbal tradition and increasingly validated by contemporary research. Empower yourself with this knowledge and integrate this advanced herbal cream into your eczema management plan, leading to the lasting comfort, clarity, and peace of mind you truly deserve.

Experience Advanced Herbal Relief for Eczema!

Ready to discover the power of natural compounds for your eczema? QICAOGANGMU Caoben Yijun Rugao offers a steroid-free herbal cream, expertly crafted with traditional Chinese herbs and supported by science, to calm inflammation, alleviate intense itching, and restore your skinโ€™s natural balance.

Why choose QICAOGANGMU? Our unique blend of Sophora flavescens, Cnidii Fructus, Borneol, and Menthol works synergistically to soothe, heal, and protect your skin. Itโ€™s a safe, gentle, and effective alternative to conventional treatments, designed for lasting comfort.

Embrace the synergy of tradition and science for your eczema care!

Unlock the benefits of natural relief:

We are so confident in our product that we offer a 100-Day Money-Back Guarantee. Try QICAOGANGMU risk-free and rediscover the comfort of healthy skin.

"I've been using QICAOGANGMU for my eczema, and it's truly remarkable how well it works. Knowing the science behind these herbs makes me trust it completely. My skin is finally calm and healthy!"

โ€” Eczema Sufferer, January 2026

"This cream is a perfect blend of ancient wisdom and modern understanding. It's gentle, incredibly effective, and has become my go-to for soothing my eczema flare-ups naturally."

โ€” Satisfied User, December 2025

References

  1. Chen HY, Lin YH, Chen YC, et al. Identifying Chinese herbal medicine network for eczema: core formulas for treating windโ€‘dampnessโ€‘heat pattern (e.g., Xiaoโ€‘Fengโ€‘San). Journal of Ethnopharmacology. 2015 Feb;179:1โ€“8. PMID: 25685167. PMID: 25685167 (Evidence Level: Network Pharmacology/Review)
  2. Cheng Hโ€‘M, Chiang Lโ€‘C, Jan Yโ€‘M, et al. The efficacy and safety of a Chinese herbal product (Xiaoโ€‘Fengโ€‘San) for the treatment of refractory atopic dermatitis: a randomized, doubleโ€‘blind, placeboโ€‘controlled trial. International Archives of Allergy and Immunology. 2011;155(2):141โ€“148. PMID: 21196758. PMID: 21196758 (Evidence Level: Clinical Study, Randomized Double-Blind Placebo-Controlled Trial)
  3. A clinical review confirms that eczema in TCM results from internal dampโ€‘heat accumulation, with treatment centered around formulas to clear heat and dispel dampness. Molecular Medicine Reports. PMCID: PMC10639001 (Evidence Level: Review Article)
  4. Lam Hโ€‘M, Leung Tโ€‘F, Ng Pโ€‘C, et al. Efficacy of a Chinese herbal medicine concoction for treatment of atopic dermatitis: a randomized, doubleโ€‘blind, placeboโ€‘controlled study. British Journal of Dermatology. 2007 Aug;157(2):357โ€“363. PMID: 17501956. PMID: 17501956 (Evidence Level: Clinical Study, Randomized Double-Blind Placebo-Controlled Study)
  5. Hon KL, Chan CL, Leung PC. Chinese herbal medicine research in eczema treatment: review of pathophysiology and clinical trials including formulas targeting windโ€‘heat and dampโ€‘heat. Chinese Medicine. 2011 Apr 28;6:17. PMCID: PMC3110124 (Evidence Level: Review Article)
  6. Xie J, Yan Y, Du Y, et al. The efficacy and safety of traditional Chinese medicine in atopic dermatitis: systematic review and metaโ€‘analysis of randomized controlled trials. Evidence-Based Complementary and Alternative Medicine. 2017;2017:6026434. PMID: 29189188. PMID: 29189188 (Evidence Level: Systematic Review and Meta-Analysis)
  7. Park Sโ€‘H, An Jโ€‘E, Jang S, Kim JY, Lee JW, Kim HK. Gardenia jasminoides extract without crocin improves atopic dermatitis-like skin lesions by suppressing Th2-related cytokines in mice. Journal of Ethnopharmacology. 2019 Sep 15;241:112015. PMID: 31173875. PMID: 31173875 (Evidence Level: In Vivo Study)
  8. Park Sโ€‘H, Jang S, An Jโ€‘E, et al. Gardenia jasminoides extract ameliorates DfEโ€‘induced atopic dermatitis in mice through restoration of barrier function and T-helper 2โ€‘mediated immune response. Biomedicine & Pharmacotherapy. 2022 Jan;145:112344. PMID: 34847477. PMID: 34847477 (Evidence Level: In Vivo Study)
  9. Lin Cโ€‘F, et al. The antiโ€‘inflammatory activity of flavonoids and alkaloids from Sophora flavescens alleviates psoriasiform lesions: Prenylation enhances skin targeting. Phytotherapy Research. 2024 Apr;38(4):1951โ€“1970. PMID: 38358770. PMID: 38358770 (Evidence Level: In Vitro/In Vivo Study)
  10. Yamaguchiโ€‘Miyamoto T, Kawasuji T, Kuraishi Y, Suzuki H. Antipruritic effects of Sophora flavescens on acute and chronic itch-related responses in mice. Biological & Pharmaceutical Bulletin. 2003 May;26(5):722โ€“724. PMID: 12736520. PMID: 12736520 (Evidence Level: In Vivo Study)
  11. Oxymatrine, an alkaloid from Sophora flavescens, significantly improves PASI scores in psoriasis patients and inhibits keratinocyte proliferation. Journal of Dermatological Treatment. 2017;28(5):463โ€“472. PMID: 28450041. PMID: 28450041 (Evidence Level: Clinical Study)
  12. Deng S, May BH, Zhang AL, Lu C, Xue CC. Topical herbal formulae (including Sophora flavescens root) improve psoriasis outcomes via anti-inflammatory, antiproliferative, angiogenic & tissue-repair actions. British Journal of Dermatology. 2013 Oct;169(4):769โ€“782. PMID: 23817996. PMID: 23817996 (Evidence Level: Review Article)
  13. Matsuda H, Ido Y, Kubo M, et al. Anti-allergic effects of Cnidium monnieri fructus and osthol in dermatitis and anaphylaxis models. Biological & Pharmaceutical Bulletin. 2002 Jun;25(6):809โ€“812. PMID: 12081154. PMID: 12081154 (Evidence Level: In Vivo Study)
  14. Tang B, et al. Chemical constituents and pharmacological activities of Cnidium monnieri (L.) Cuss. Molecules. 2020 Jan 29;25(3):575. PMID: 32028721. PMID: 32028721 (Evidence Level: Review Article)
  15. Li ZY, et al. Borneol significantly reduced acute and chronic itch in mice and patients by modulating TRPA1 and TRPM8 ion channels. Frontiers in Pharmacology. 2023 Nov 29;14:1288289. PMID: 38103845. PMID: 38103845 (Evidence Level: In Vivo/Clinical Study)
  16. He J, et al. Topical borneol alleviated inflammation and pain by inhibiting macrophage/lymphocyte infiltration and downregulating ILโ€‘6, TNFโ€‘ฮฑ, ILโ€‘8. Journal of Pain Research. 2020 Jan 20;13:163โ€“172. PMID: 31978868. PMID: 31978868 (Evidence Level: In Vivo Study)
  17. Jamal N, et al. Menthol-based cream enhanced wound healing in rats by decreasing TNFโ€‘ฮฑ & ILโ€‘6, boosting antioxidant enzymes, and reducing inflammation. Pharmaceutical Biology. 2021 Dec;59(1):1532โ€“1539. PMID: 34834317. PMID: 34834317 (Evidence Level: In Vivo Study)
  18. Derma UK. The Benefits of Menthol. Menthoderm. 2017. Derma UK Link (Evidence Level: Product Information/Review)
  19. Kim H, Lee MR, An WG, Cho SI. Effect of Sophora flavescens extract on degranulation of mast cells and contact dermatitis induced by DNFB in mice. Journal of Ethnopharmacology. 2012 Jun;142(1):253โ€“258. PMID: 22580027. PMID: 22580027 (Evidence Level: In Vivo Study)

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any new treatment or if you have any medical concerns. Individual results may vary.

ยฉ 2025 Qicaogangmu. All rights reserved.

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